Profile Summary

Medical Qualification:

MD, DNB (Medicine), DM, DNB (Neurology)

Fellowship in Movement Disorders (2006-2008) University of Toronto

Areas of expertise :

• Treating patients with Parkinson’s disease (PD), Parkinsonism, Dystonia, Tremors, Wilson’s disease, Tourette’s syndrome and other Movement Disorders. 
• Injecting botulium toxin for focal dystonia – cervical, blepharospasm and focal hand dystonia, hemifacial spasms, spasticity and migraine with or without EMG guidance
• Selecting and Programming patients with movement disorders requiring deep brain stimulation. 

Introduction:

Dr. Pettarusp M. Wadia completed his neurology training from the Topiwala National Medical College, followed by a Movement Disorders fellowship at the University of Toronto, Canada under Dr. Anthony Lang and Dr. Elena Moro where he had a dedicated 6-month training program in programming patients with Deep Brain Stimulation. He presented his paper on restlessness in parkinsonism at the prestigious American Academy of Neurology . He is serving at Jaslok Hospital and Research Center since October 2008, treating patients with Parkinson’s disease (PD), and other Movement Disorders. 

Dr. Wadia is a teacher in neurology for the DNB neurology course and is the program coordinator of the Clinical Fellowship program in Movement Disorders at Jaslok Hospital and Research Centre Mumbai. 

Dr. Wadia’s ongoing research projects include the role of TRODAT scans in drug induced parkinsonism and atypical parkinsonism, clinical phenotype of patients with SCA-12 and directional DBS in PD. He is the principal investigator in a genome wide association study of patients with PD and a phase II research trial of a drug being evaluated for neuropection in PD. 

Awards & Publications :

Dr. Pettarusp Wadia has written 40 research papers, 9 book chapters and has been the Co-Editor of the second edition of the text book of Parkinson’s disease and Movement Disorders. 
 

Scientific Publications :

• A. Aundhakar, A. Nanavati, B. Mishal, P. Wadia ‘A study of seven patients with Hemimasticatory spasm; barriers to treatment and outcomes of botulinum toxin’. Mov Disord. 2022; 37 (suppl 1) page S 40
• VM. Mathur, PD. Doshi, AA. Aundhkar, MB. Baldia, P. Wadia. Directional DBS – Early experiences with “Current steering” in India [abstract]. Mov Disord. 2022; 37 (suppl 1). Page S458
• Kukkle PL,Geetha TS, Chaudhary R ,Sathirapongsasuti JF, Goyal, Kandadai RM ,Kumar H, , Borgohain R ,Mukherjee A, Oliver M, Meeta S, Mootor MFE, Kapil S, Mandloi N, Wadia PM, Yadav R, Desai S,  Kumar N, Biswas A, ,Pal PK, Muthane UB,  Das SK. Sakthivel SM, Peterson AS, Stawiski ES, Seshagiri S, Gupta R, Ramprasad VL, Parkinson Research Alliance of India (PRAI). Genome-Wide Polygenic Score Predicts Large Number of High-Risk Individuals in Monogenic Undiagnosed Young Onset Parkinson's Disease Patients from India. Advanced Biology, First published online 10 July 2022. https://doi.org/10.1002/adbi.202101326
• Baldia Manish, Wadia Pettarusp M, Karkera Bharti, Mathur Vaibhav, Doshi Paresh K. Predictability of the effective contact point with help of beta band local field potentials obtained from Percept PC device while programming in advanced Parkinson’s patients. Annals of Movement Disorders 2022, Volume 5, supplement 1, S11
• Mohan Meenu, Luthra Karuna, Lele Vikram R, Wadia Pettarusp M, Clinical utility of 18F-DOPA PET/CT in Parkinsonism and concordance with 99mTc-TRODAT-1 SCAN. Annals of Movement Disorders 2022, Volume 5, supplement 1, S11
• Korepu Priyanka, Lele Viram R, Wadia Pettarusp M, Karnavat Chandresh, Shah Hina J. Blinded comparative analysis of 99mTc-TRODAT SPECT-CT, FDG PET-CT and MRI scans in the diagnosis of Parkinsonism at a tertialry care centre in Mumbai during the period of 2010-2018: A cross sectional retrospective and prostpective study. Annals of Movement Disorders 2022, Volume 5, supplement 1, S18-20
• Aundhakar Aditya, Nanavati Anvit, Mishal Bhushan, Wadia Pettarusp M. A study of seven patients with hemimasticatory spasms: Barriers to treatment and outsomes of botulinum toxin. Annals of Movement Disorders 2022, Volume 5, supplement 1, S55-56
• Mathur Vaibhav, Doshi Paresh K, Aundhakar Aditya, Baldia Manish, Wadia Pettarusp M. Directional DBS-Early experiences with “Current steering” in India. Annals of Movement Disorders 2022, Volume 5, supplement 1, S59-60
• Kukkle PL, Goyal V, Geetha TS, Mridula KR, Kumar H, Borgohain R, Mukherjee A, Wadia PM, Yadav R, Desai S, Kumar N, Gupta R, Biswas A, Pal PK, Muthane U, Das SK, Quinn N, Ramprasad VL; Parkinson Research Alliance of India (PRAI). Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson's Disease. Can J Neurol Sci. 2021 Mar 9:1-9. doi: 10.1017/cjn.2021.40. Epub ahead of print. PMID: 33685545.
• Prashant LK, Kumar H, Wadia PM, Muthane U. The Spectrum Of Movement Disorders In Tertiary Care Centers In India : A Tale Of Three Cities. Annals of Indian Academy of Neurology. DOI: 10.4103/aian.AIAN_1257_20
• Kumar Niraj, Gupta Ravi, Kumar Hrishikesh, Mehta Sahil, Rajan Roopa, Kumar DVS, Mridula RK, Desai S, Wadia P, Basu Purba, Mondal B, Sanchita , Rawat A, Meka SS, Mishal B, Prashanth LK, Srivastava AK, Goyal V. Impact of home confinement during COVID-19 pandemic on sleep parameters in Parkinson's disease. Sleep Med. 2021 Jan;77:15-22. doi: 10.1016/j.sleep.2020.11.021. Epub 2020 Nov 23
• Kumar N, Gupta R, Kumar H, Mehta S, Rajan R, Kumar D, Kandadai RM, Desai S, Wadia P, Basu P, Mondal B, Sanchita, Rawat A, Meka SS, Mishal B, Prashanth LK, Srivastava AK, Goyal V. Impact of home confinement during COVID-19 pandemic on Parkinson's disease. Parkinsonism Relat Disord. 2020 Sep 6;80:32-34. doi: 10.1016/j.parkreldis.2020.09.003. Epub ahead of print. PMID: 32937224; PMCID: PMC7474806.
• Mishal BR, Kachhadiya KJ, Wadia PM. Hyperparathyroidism - a rare cause of worsening of parkinsonism, Annals of Movt Disorders 2020: 3 (3) 181-184
• Irani AM, Kachhadiya KJ, Wadia PM. Orobuccolingual dyskinesia- A rare complication following Gas Geyser Encephalopathy. Annals of Indian Academy of Neurology. Accepted for publication July 2020
• Meoni S, Bradi AC, Wadia P, Poon YY, Moro E. Dyspnea after subthalamic deep brain stimulation in Parkinson's disease: a case-control study. J Neurol. 2020 Oct;267(10):3054-3060. doi: 10.1007/s00415-020-09976-0. Epub 2020 Jun 10. PMID: 32524258.
• Rajan R, Divya Kp, Mridula RK, Venkata P. Satagopam, Madhusoodanan UK, Agarwal P, Kumar N, Ferreira T, Kumar H, Prasad S Av, Shetty K, Mehta S, Desai S, Kumar S., Prashanth L K, Bhatt M, Wadia P, Ramalingam S, Wali GM, Pandey S, Bartusch F., Hannussek M., Krüger J, Kumar-Sreelatha A, Grover S, Sturm M, Lichtner P., Roeper J., Busskamp V., Chandak GR, Schwamborn JC, Seth P, Gasser T, Riess O, Goyal V, Pal PK, Borgohain R, Krueger R, Kishore A, Sharma M.. Genetic architecture of Parkinson’s disease in the Indian population: Harnessing genetic diversity to address critical gaps in Parkinson’s Disease research. Frontiers in Neurology 2020.11(524)
• Mishal BR, Shetty AS, Doshi PK, Wadia PM. A retrospective analysis of drug therapy modifications following STN DBS. Annals of Mov. Disord. 2020: 3, Supplement, S6
• Nagral A, Sarma MS, Matthai J, Kukkle PL, Devarbhavi H, Sinha S, Alam S, Bavdekar A, Dhiman RK, Eapen CE, Goyal V, Mohan N, Kandadai RM, Sathiyasekaran M, Poddar U, Sibal A, Sankaranarayanan S, Srivastava A, Thapa BR, Wadia PM, Yachha SK, Dhawan A. Corrigendum to "Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for the Study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI)" [J Clin Exp Hepatol 9 (2019) 74-98]. J Clin Exp Hepatol. 2020 Jan-Feb;10(1):99. doi: 10.1016/j.jceh.2019.12.001. Epub 2019 Dec 10. Erratum for: J Clin Exp Hepatol. 2019 Jan-Feb;9(1):74-98. PMID: 32025169; PMCID: PMC6995886.
• Nagral A, Sarma MS. Matthai J, Kukkle PL, Devarbhavi H, Sinha S, Alam A, Bavdekar A, Dhiman RK, Eapen C, Goyal V, Mohan N, Kandadai RM, Malathi Sathiyasekaran, Poddar U, Sibal A, Sankaranarayanan S, Srivastava A, Thapa BR, Wadia PM, Yachha SK, Dhawan A. Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India. J. of Clin and Exp Hepatology https://doi.org/10.1016/j.jceh.2018.08.009
• Mestre TA, Pont-Sunyer C, Kausar F, Visanji N P, Ghate T, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ,  Gaust‐Socher A, Kasten M, Wadia PM, Zadikoff C, Kumar P, De Bie RM, Thomsen T,  Lang AE, Shule B, Klein C, Tolossa E, Marras C. Clustering of motor and non-motor traits in LRRK2G2019S Parkinson disease non-parkinsonian relatives. Mov. Disorder 2018; 33 (6): 960-965
• Shetty AS, Kashikar R, Nagral A, Wadia PM. Cortical Cystic Necrosis in Wilson disease. JAMA Neurology 2016; 73(3):350-1
• Shah PA, Wadia PM. Reversible man-in-the-barrel syndrome in Myasthenia Gravis. Ann Indian Acad of Neurol 2016;19(1) 99-101
• Shetty AS, Shah HJ, Lele VR, Wadia PM. Drug induced Parkinsonism: Role of functional imaging and follow up. Mov Disord. 2016; 31 (Suppl 2) S73
• Wadia PM, Khanna JN. Task Specific Oromandibular Dystonia secondary to chewing Khat (Cantha edulis). Mov Disord (Suppl 1) 2015
• Lim SY, Wadia PM, Armstrong MJ, Schenk CH, Lang AE. Augmented Restless Legs Syndrome with Marked Hyperkinesias and Impulsive-Compulsive Behaviors. Mov Disord Clin Practice 2015; 3:412-414
• Doshi PK, Joy D, Karkera B, Wadia PM. Bilateral pedunculopontine nucleus stimulation for progressive supranuclear palsy; Stereotactic and Functional Neurosurgery 2015;93:59–65
• Wadia PM, Howard P, Ribeirro M, Robble J, Asante A, Mikulis D, Lang AE. The value of GRE, ADC and routine MRI in distinguishing parkinsonian disorders, Canadian Journal of Neurol Sciences, 2013; 40: 389-402
• Wadia PM, Barretto M, Lalkaka JS, Devare S, Dyas K, Singhal BS. Non-motor fluctuations in patients with Parkinson’s disease. Mov Disord. 2012; 27 (suppl 1): S315 (943)
• Zadikoff, C., Wadia, PM., Miyasaki, J., Chen, R., Lang, A. E., So, J., & Fox, S. H. (2011). Cannabinoid, CB1 agonists in cervical dystonia: Failure in a phase IIa randomized controlled trial. Basal Ganglia, 2011, 1(2), 91-95. 
• Wadia PM, Tan G, Munhoz RP, Fox SH, Lewis SJ, Lang AE. Surgical correction of kyphosis in patients with Camptocormia due to Parkinson’s disease – A retrospective evaluation. J Neurol Neurosurg Psych 2011;82(4):364-368
• Marras C, Schule B, Munhoz RP, Rogaeva, E, Langston JW, Kasten M, Meaney C, Klein C, Wadia PM, Lim SY, Chuang RS, Zadikof C, Steeves T., Prakash KM, De Bie RM, Adeli G, Thomsen T, Johansen KK, Teive HA, Asante A, Reginold W, Lang AE. Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers. Neurology 2011;77:325-333
• Wadia PM, Lim SY, Lozano AM, Adams JR, Y Poon, C Torresdiaz, Moro E. Bilateral Pallidal Stimulation for X Linked Dystonia Parkinsonism (XDP). Archives of Neurol 2010;67(8):1012-1015
• Lim SY, Wadia PM, Wenning GK, Lang AE. Clinically probable multiple system atrophy with predominant parkinsonism associated with myotonic dystrophy type 2. Mov Disord 24:1407-9.2009
• Zadikoff C, Fox SH, Tang-Wai DF, Thomsen T, de Bie RM, Wadia P, Miyasaki J, Duff-Canning S, Lang AE, Marras C. A comparison of the mini mental state exam to the Montréal cognitive assessment in identifying cognitive deficits in Parkinson's disease. Mov Disord 23:297-299.2008
• Sanghani NR, Shah AB, Wadia PM, Jain N, Menon RS. Subtypes of ischemic strokes – a hospital based stroke registry in India. Int. J. Of Stroke 3(suppl 1):307-308.2008
• Thomsen T, Miyasaki J.M, Zurowski M, De Sousa M, De Bie RMA, Wadia P, Adeli G, and Lang AE, V. Voon V. Pathological hypersexuality in Parkinson’s disease: A clinician rated survey and a working definition. Mov Disord 2007; 22 (suppl 16): 309.2008
• Wadia PM, Lang AE. The many faces of corticobasal degeneration. Parkinsonism and Related Disorders 2007: 13:S336-S340
• Wadia P, Shah A, Kandhari S, Hegde V.  Use intravenous recombinant Tissue Plasminogen Activator in acute ischemic strokes from a tertiary care centre in a developing country. Journal of Neurol. Sci. 238(suppl-1):S452.2005  (presented at the World Federation of Neurology in Sydney, 2005)
• Wadia P, Shah A. A Study of Epilepsy in the Elderly population of India. Epilepsia 2005;46(S6): 292 (Received a young investigator award at the ILAE conference in Paris, 2005 for the same)
• Shah A, Wadia P, Baviskar R, Ramdass R. Motor fluctuations in Juvenile Parkinsonism – Management dilemma. Mov Disord 2005; 20 (supplement 10): S110
• Book Chapters
• Wadia Pettarusp Murzban, Irani Azad Marazban, Japanese Encephalitis, Page 288-292, In Sandhya A Kamath, API textbook of Medicine In Sandhya A Kamath edited, 12th edition, Volume 1. Jaypee Brothers Medical Publishers
• Tipnis N, Doshi PK, Wadia PM, Surgical Management of Parkinson’s disease. Page 180-187, In Kalyan B. Bhattacharya editted, 2nd Edition Parkinson’s Disease and Movement Disorders. Jaypee Publication
• Barfiwala VA, Irani AM, Wadia PM, Drug induced Movement Disorders. Page 359-368, In Kalyan B. Bhattacharya editted, 2nd Edition Parkinson’s Disease and Movement Disorders. Jaypee Publication
• Mishal Bhushan, Wadia Pettarusp Murzban, Atypical Parkinsonism, Page 69-85 in Lakshmi Narasimhan Rananathan edited Reviews in Neurology 2020. Movement Disorders: Indian Perpsective. Wolter Kluwer
• Wadia Pettarusp M, Japanese encephalitis, In Sandhya A Kamath editted in API Text book of Medicine 11th Edition. CBS Publishers & Distributors 2019. 
• Irani AM, Wadia PM. Huntington’s disease. In Mukherjee Arabinda ed in IAN text book of Neurology. Jaypee publication 2018. 432-436
• Irani AM, Wadia PM. Restless Leg Syndrome. In Mukherjee Arabinda ed in IAN text book of Neurology. Jaypee publication 2018.  378-382 
• Wadia PM. Deep brain stimulation in Movement Disorders. In Kumar Ashok ed. Textbook of Movement Disorders. Jaypee publication 2014. 
• Wadia PM, Lang AE, Moro E. Selecting appropriate dystonic patients for GPi Stimulation. In: Bain P, Aziz T, Liu X, Nandi D, eds. Deep Brain Stimulation. Oxford: Oxford University Press, 2009: 107-125.

Memberships :

Dr. Wadia is the founding member of Movement Disorder Society of India and an active member of the international Parkinson’s disease and Movement Disorders Society and Indian Academy of Neurology,. He is on the governing council of Parkinson’s disease and Movement Disorder Society (PDMDS) an NGO for persons with PD.